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Melissa J Reed Selected Research

isopimpinellin

3/2003Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells.
10/2002Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice.
2/2002Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.

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Melissa J Reed Research Topics

Disease

3Neoplasms (Cancer)
03/2003 - 02/2002
1Adenocarcinoma
03/2003
1Papilloma (Papillomatosis)
10/2002
1Carcinogenesis
02/2002
1Hepatocellular Carcinoma (Hepatoma)
02/2002

Drug/Important Bio-Agent (IBA)

3imperatorinIBA
03/2003 - 02/2002
3anthraceneIBA
03/2003 - 02/2002
3isopimpinellinIBA
03/2003 - 02/2002
2Benzo(a)pyreneIBA
03/2003 - 10/2002
2bergamottinIBA
03/2003 - 02/2002
2Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA
03/2003 - 02/2002
2Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
03/2003 - 02/2002
2DNA AdductsIBA
03/2003 - 10/2002
1CoumarinsIBA
03/2003
1CarcinogensIBA
03/2003
1Corn Oil (Oil, Corn)IBA
10/2002
1coumarinIBA
10/2002
1AcetoneIBA
02/2002
1Furocoumarins (Furanocoumarins)IBA
02/2002
1alpha-naphthoflavoneIBA
02/2002

Therapy/Procedure

1Oral Administration
10/2002